This medication is a combination of 2 medications: lumacaftor and ivacaftor. It is used to treat cystic fibrosis in certain people (those with 2 copies of an abnormal “CFTR” gene). It may help to improve breathing, reduce the risk of lung infections, and improve weight gain.
Lumacaftor-Ivacaftor Tablet – COMMON BRAND(S): ORKAMBI. GENERIC NAME(S): LUMACAFTOR-IVACAFTOR
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Lumacaftor/ivacaftor, sold under the brand name Orkambi among others, is a combination of lumacaftor and ivacaftor used to treat people with cystic fibrosis who have two copies of the F508del mutation. It is unclear if it is useful in cystic fibrosis due to other causes. It is taken by mouth.
It was approved for medical use in the United States in 2015, and in Canada in 2016. In the United States it costs more than $US 22,000 a month as of 2018. While its use was not recommended in the United Kingdom as of 2018,[pricing was agreed upon in 2019 and it is expected to be covered by November of that year.