A drug used with other drugs to treat breast cancer that is HER2 positive. It is used in patients whose cancer has spread to other parts of the body and has not already been treated with other anticancer drugs. It is also used before surgery in patients with locally advanced, inflammatory, or early-stage breast cancer and after surgery in patients with early-stage breast cancer who have a high risk that their cancer will recur (come back). It is also being studied in the treatment of other types of cancer. Pertuzumab binds to a protein called HER2, which is found on some cancer cells. Blocking this protein may help kill cancer cells. Pertuzumab is a type of monoclonal antibody. Also called Perjeta. US Brand Name(s): Perjeta. FDA Approved: Yes
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Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.
Pertuzumab is administered as an intravenous infusion in combination with trastuzumab and docetaxel as a first line treatment for HER2-positive metastatic breast cancer. It is also used in the same combination as a neoadjuvant (given to reduce the size of a tumor, prior to surgery or radiation) for HER2-positive early breast cancer; as of 2016 this use had not been shown to increase survival
Pertuzumab is approved to be used with trastuzumab and either docetaxel or other drugs to treat:
Breast cancer that is HER2 positive (HER2+). I
Pertuzumab is also available in a different form, combined with trastuzumab and hyaluronidase. For more information, see the Drug Information Summary for Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf.
Pertuzumab is also being studied in the treatment of other types of cancer.