A drug used to treat thrombocytopenia (a low blood platelet count) in adults and in certain children with immune thrombocytopenic purpura that did not get better with other treatment. It is also being studied in the treatment of other conditions and types of cancer. Romiplostim binds to the thrombopoietin receptor, which causes the bone marrow to make more platelets. It is a type of thrombopoietin receptor agonist. Also called AMG 531 and Nplate.
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The drug was developed by Amgen through a restricted usage program called NEXUS. During development and clinical trials the drug was called AMG531.[citation needed]
Romiplostim is indicated as a potential treatment for chronic idiopathic (immune) thrombocytopenic purpura (ITP). Romiplostim was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2003
On August 22, 2008, the FDA approved romiplostim as a long-term treatment for chronic ITP in adults who have not responded to other treatments, such as corticosteroids, intravenous immunoglobulin, Rho(D) immune globulin or splenectomy.
Romiplostim For subcutaneous injection
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