A drug used to treat adults and children aged 1 year and older with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. It is used in patients whose cancer has not gotten better or has recurred (come back) after treatment with other anticancer drugs. Nelarabine stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. Also called 506U78 and Arranon. US Brand Name(s): Arranon FDA Approved: Yes
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Nelarabine, sold under the brand names Arranon (US) and Atriance (EU), is a chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).
Nelarabine is a prodrug of arabinosylguanine nucleotide triphosphate (araGTP), a type of purine nucleoside analog, which causes inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens. It was later approved in the European Union in October 2005. Complete responses have been achieved with this medication.
Use in Cancer
Nelarabine is approved to treat adults and children aged 1 year or older with:
T-cell acute lymphoblastic leukemia.
T-cell lymphoblastic lymphoma.
Nelarabine is used in patients whose disease has not gotten better with other treatment or has recurred (come back) after at least two chemotherapy regimens.