A drug used to treat women with certain types of hormone-receptor positive, HER2-negative breast cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Ribociclib succinate blocks certain proteins, which may help keep cancer cells from growing. It is a type of cyclin-dependent kinase inhibitor. Also called Kisqali. US Brand Name(s): Kisqali FDA Approved: Yes
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Ribociclib, sold under the brand name Kisqali and Kryxana marketed by Novartis, is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of certain kinds of breast cancer. Ribociclib is a kinase inhibitor indicated in combination with: an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy; or fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, as initial endocrine-based therapy or following disease progression on endocrine therapy
Ribociclib was approved by the U.S. Food and Drug Administration (FDA) in March 2017. It was approved by the European Medicines Agency (EMA) in August 2017. It was approved for use in the NHS by NICE in February 2021. It can be used in combination with an aromatase inhibitor (such as letrozole) to treat HR-positive, HER2-negative advanced or metastatic breast cancers
Ribociclib is approved to be used with other drugs to treat:
Breast cancer that is hormone receptor positive (HR+) and HER2 negative (HER2-) and is advanced or has metastasized (spread to other parts of the body). Ribociclib is also being studied in the treatment of other types of cancer.
ribociclib tablets
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