Food and Drug Administration approved abemaciclib (Verzenio,Eli Lilly and Company)with endocrine therapy (tamoxifen or an aromatase inhibitor) for adjuvant treatment of adult patients with hormone receptor (HR)-positive
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These drugs are approved for women with advanced hormone receptor-positive, HER2-negative breast cancer and are taken as pills, typically once or twice a day.
There are different ways to use these drugs.
- Any of the three drugs can be given along with an aromatase inhibitor (AI) or fulvestrant to women who have gone through menopause.
- Any of these three drugs can also be given with fulvestrant or an aromatase inhibitor to women who are still having regular periods (premenopausal) or are almost in menopause (perimenopausal). These women, however, must also be on medicines, such as luteinizing hormone-releasing hormone (LHRH) analogs, that stop the ovaries from making estrogen or have their ovaries removed with surgery.
- Abemaciclib can also be used by itself in women who have previously been treated with hormone therapy and chemotherapy.