A drug used to treat hepatic veno-occlusive disease (a condition in which small veins in the liver are blocked) in adults and children who also have kidney or lung problems after receiving a stem cell transplant. Defibrotide sodium may affect the cells that line the inside of blood vessels and may help improve blood flow inside the liver. Also called Defitelio. US Brand Name(s): Defitelio.
FDA Approved: Yes
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Defibrotide, sold under the brandname Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs. It is used to treat veno-occlusive disease of the liver of people having had a bone marrow transplant, with different limitations in the US and the European Union. It works by protecting the cells lining blood vessels in the liver and preventing blood clotting; the way it does this is not well understood.
Use in Cancer
Defibrotide sodium is approved to treat:
Hepatic veno-occlusive disease (also known as sinusoidal obstruction syndrome) in adults and children who also have kidney or lung problems after receiving a stem cell transplant.